The search for safe and efficient chronic pain treatments is dampened by the lack of reliable models that faithfully reproduce current pharmacological treatments for chronic spontaneous pain in humans. Preclinical models often assess the antinociceptive efficacy of non-contingent pharmacological treatments evaluated in the short-term. Here. we provide a protocol of contingent operant ... https://www.littletreehouselanes.shop/product-category/bottle-dishwasher-cage/