Summary: The emergence of the SARS-CoV-2 Omicron variant is dominant in many countries worldwide. The high number of spike mutations is responsible for the broad immune evasion from existing vaccines and antibody drugs. To understand this. we first present the cryo-electron microscopy structure of ACE2-bound SARS-CoV-2 Omicron spike. https://www.steedaes.shop/product-category/exteriors/